Neurocognitive and neuroimaging biomarkers: predicting progression towards dementia in patients with treatment-resistant late-life depression (Optimum Neuro)

Optimum Neuro is a longitudinal, multi-site study utilizing comprehensive neuropsychological testing, brain imaging, and bloodwork to examine cognitive trajectories in late-life treatment resistant depression.

Ambulatory cognitive evaluation and psychosocial functioning in older adults at risk for cognitive decline (ACE)

ACE is a cross-sectional, observational study that draws from several ongoing Pitt cohorts. Learn More

Fitness for Brain Optimization for Late-Life Depression (FITBOLD)

FITBOLD is an randomized interventional study designed to understand the role of aerobic exercise in preserving brain health in recently depressed older adults. Learn More

Caregiver Stress and Sleep Study (CARES)

CARES is a randomized controlled clinical trial aimed to better understand how and when activity might impact caregivers’ mood.

Sleep-wake, cognitive, and affective risks for a worse course of post-discharge suicidal ideation in older adults with major depression (Post-RAR)

Post-RAR is an observational study whose purpose is to better understand the experiences of people with depression and suicidality.

Pittsburgh Hill/Homewood Research on Neighborhood Change and Health (PHRESH)

PHRESH is part of an ongoing study of the Hill District and Homewood communities in the City of Pittsburgh. We are examining features of the built and social environment over time, and documenting to what extent changes impact residents’ health and well-being, diet, exercise, sleep, and heart health. Learn More

Characterizing activity pattern disruption to target for preventing post-stroke depression (Post-Stroke)

Post-Stroke is an evaluation of depression symptoms in response to modifying targets of sleep/wake activity patterns in a group of stroke survivors. Learn More